4bjc: Difference between revisions

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~~{{STRUCTURE_4bjc| PDB=4bjc | SCENE= }}~~

==Crystal structure of human tankyrase 2 in complex with Rucaparib==

===Crystal structure of human tankyrase 2 in complex with Rucaparib===

== Structural highlights ==

<table><tr><td colspan='2'>[[4bjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJC OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJC FirstGlance].

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=RPB:RUCAPARIB'>RPB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>

<tr><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4bj9|4bj9]], [[4bjb|4bjb]]</td></tr>

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </td></tr>

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bjc RCSB], [http://www.ebi.ac.uk/pdbsum/4bjc PDBsum]</td></tr>

<table>

==~~Function~~==

==See Also==

[[~~http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]]~~ Poly-ADP-~~ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-~~ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</~~ref~~>

*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]

__TOC__

~~==About this Structure==~~

</StructureSection>

[[~~4bjc~~]] ~~is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJC OCA].~~

[[Category: Human]]

~~==Reference==~~

~~<references group="xtra"/><references/>~~

[[Category: Haikarainen, T.]]

[[Category: Lehtio, L.]]

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-{{STRUCTURE_4bjc|  PDB=4bjc  |  SCENE=  }}
+==Crystal structure of human tankyrase 2 in complex with Rucaparib==
-===Crystal structure of human tankyrase 2 in complex with Rucaparib===
+<StructureSection load='4bjc' size='340' side='right' caption='[[4bjc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4bjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJC FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RPB:RUCAPARIB'>RPB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bj9|4bj9]], [[4bjb|4bjb]]</td></tr>
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bjc RCSB], [http://www.ebi.ac.uk/pdbsum/4bjc PDBsum]</span></td></tr>
+<table>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
+*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4bjc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJC OCA].
+[[Category: Human]]
-==Reference==
-<references group="xtra"/><references/>
 [[Category: Haikarainen, T.]]
 [[Category: Lehtio, L.]]