1bqm: Difference between revisions

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[[Image:1bqm.gif|left|200px]]<br /><applet load="1bqm" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1bqm.gif|left|200px]]
caption="1bqm, resolution 3.1&Aring;" />
 
'''HIV-1 RT/HBY 097'''<br />
{{Structure
|PDB= 1bqm |SIZE=350|CAPTION= <scene name='initialview01'>1bqm</scene>, resolution 3.1&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=HBY:(S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE'>HBY</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE=
}}
 
'''HIV-1 RT/HBY 097'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1BQM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) Human immunodeficiency virus type 1 (isolate 12)] with <scene name='pdbligand=HBY:'>HBY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQM OCA].  
1BQM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) Human immunodeficiency virus type 1 (isolate 12)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQM OCA].  


==Reference==
==Reference==
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance., Hsiou Y, Das K, Ding J, Clark AD Jr, Kleim JP, Rosner M, Winkler I, Riess G, Hughes SH, Arnold E, J Mol Biol. 1998 Nov 27;284(2):313-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9813120 9813120]
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance., Hsiou Y, Das K, Ding J, Clark AD Jr, Kleim JP, Rosner M, Winkler I, Riess G, Hughes SH, Arnold E, J Mol Biol. 1998 Nov 27;284(2):313-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9813120 9813120]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus type 1 (isolate 12)]]
[[Category: Human immunodeficiency virus type 1 (isolate 12)]]
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[[Category: Hsiou, Y.]]
[[Category: Hsiou, Y.]]
[[Category: HBY]]
[[Category: HBY]]
[[Category: aids]]
[[Category: aid]]
[[Category: drug-resistant mutant]]
[[Category: drug-resistant mutant]]
[[Category: hiv-1 rt/hby 097]]
[[Category: hiv-1 rt/hby 097]]
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[[Category: rna-directed dna polymerase]]
[[Category: rna-directed dna polymerase]]


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