1bqu: Difference between revisions
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[[Image:1bqu.gif|left|200px]] | [[Image:1bqu.gif|left|200px]] | ||
'''CYTOKYNE-BINDING REGION OF GP130''' | {{Structure | ||
|PDB= 1bqu |SIZE=350|CAPTION= <scene name='initialview01'>1bqu</scene>, resolution 2.00Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | |||
|ACTIVITY= | |||
|GENE= IL6ST ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''CYTOKYNE-BINDING REGION OF GP130''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BQU is a [ | 1BQU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQU OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of a cytokine-binding region of gp130., Bravo J, Staunton D, Heath JK, Jones EY, EMBO J. 1998 Mar 16;17(6):1665-74. PMID:[http:// | Crystal structure of a cytokine-binding region of gp130., Bravo J, Staunton D, Heath JK, Jones EY, EMBO J. 1998 Mar 16;17(6):1665-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9501088 9501088] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: interleukine 6 receptor beta subunit]] | [[Category: interleukine 6 receptor beta subunit]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:14:32 2008'' | ||
Revision as of 08:14, 20 March 2008
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| 1bqu, resolution 2.00Å | |||||||||||||
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| Ligands: | SO4 and GOL | ||||||||||||
| Gene: | IL6ST (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CYTOKYNE-BINDING REGION OF GP130
Overview
The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain.
About this Structure
1BQU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a cytokine-binding region of gp130., Bravo J, Staunton D, Heath JK, Jones EY, EMBO J. 1998 Mar 16;17(6):1665-74. PMID:9501088
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