3uke: Difference between revisions

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[[~~Image~~:~~3uke~~.~~png~~|~~left~~|~~200px~~]]

==(S)-cMOE-BNA decamer structure==

== Structural highlights ==

<table><tr><td colspan='2'>[[3uke]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UKE FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSM:1-{2,5-ANHYDRO-6-O-METHYL-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-MANNOFURANOSYL}PYRIMIDINE-2,4(1H,3H)-DIONE'>CSM</scene></td></tr>

<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ukb|3ukb]], [[3ukc|3ukc]]</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uke RCSB], [http://www.ebi.ac.uk/pdbsum/3uke PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.

~~{{STRUCTURE_3uke| PDB=3uke | SCENE= }}~~

Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.,Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M Chem Commun (Camb). 2012 May 22. PMID:22614180<ref>PMID:22614180</ref>

~~===(S)-cMOE-BNA decamer structure===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_22614180}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[3uke]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3UKE OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:022614180<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Egli, M.]]

[[Category: Pallan, P S.]]

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@@ Line 1: / Line 1: @@
-[[Image:3uke.png|left|200px]]
+==(S)-cMOE-BNA decamer structure==
+<StructureSection load='3uke' size='340' side='right' caption='[[3uke]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3uke]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UKE FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSM:1-{2,5-ANHYDRO-6-O-METHYL-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-MANNOFURANOSYL}PYRIMIDINE-2,4(1H,3H)-DIONE'>CSM</scene></td></tr>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ukb|3ukb]], [[3ukc|3ukc]]</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uke RCSB], [http://www.ebi.ac.uk/pdbsum/3uke PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.
-{{STRUCTURE_3uke|  PDB=3uke  |  SCENE=  }}
+Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.,Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M Chem Commun (Camb). 2012 May 22. PMID:22614180<ref>PMID:22614180</ref>
-===(S)-cMOE-BNA decamer structure===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_22614180}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3uke]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKE OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:022614180</ref><references group="xtra"/>
 [[Category: Egli, M.]]
 [[Category: Pallan, P S.]]