Squalene synthase

<StructureSection load='3wef' size='340' side='right' caption='Structure of human SQS complex with FPP analog and Mg+2 (green) (PDB code 3wef).' scene=>

Function

Squalene synthase (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol.

3D structures of squalene synthase

Updated on 15-June-2014

3vj8, 3vjb – hSQS – human
1ezf – hSQS (mutant)

SQS complexes

3lee – hSQS + Mg + bisphosphonate inhibitor
3asx, 3q2z, 3q30 – hSQS + Mg + PO4 + inhibitor
3vj9, 3vja – hSQS + Ni
3vjc – hSQS + Mg + PO4 + zaragozic acid
3v66 – hSQS + PO4 + inhibitor
3wef – hSQS + FPP analog
3weg – hSQS + Mg + FPP analog
3weh – hSQS + Mg + presqualene pyrophosphate
3wei – hSQS (mutant) + Mn + presqualene pyrophosphate
3wej, 3wek – hSQS (mutant) + Mg + presqualene pyrophosphate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky