1bzf: Difference between revisions

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[[Image:1bzf.gif|left|200px]]<br /><~~applet load~~=~~"1bzf" size~~=~~"350" color~~=~~"white" frame~~=~~"true" align~~=~~"right" spinBox~~=~~"true"~~

[[Image:1bzf.gif|left|200px]]

~~caption~~=~~"1bzf" />~~

'''NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES'''~~<br />~~

{{Structure

|PDB= 1bzf |SIZE=350|CAPTION= <scene name='initialview01'>1bzf</scene>

|SITE= <scene name='pdbsite=TMQ:Residues+w.+Observed+Noes+To+Bound+Trimetrexate'>TMQ</scene>

|LIGAND= <scene name='pdbligand=TMQ:TRIMETREXATE'>TMQ</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]

|GENE=

}}

'''NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES'''

==Overview==

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==About this Structure==

1BZF is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with <scene name='pdbligand=TMQ:'>TMQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Known structural/functional Site: <scene name='pdbsite=TMQ:Residues+w.+Observed+Noes+To+Bound+Trimetrexate'>TMQ</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BZF OCA].

1BZF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BZF OCA].

==Reference==

Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate., Polshakov VI, Birdsall B, Frenkiel TA, Gargaro AR, Feeney J, Protein Sci. 1999 Mar;8(3):467-81. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~10091649 10091649]

Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate., Polshakov VI, Birdsall B, Frenkiel TA, Gargaro AR, Feeney J, Protein Sci. 1999 Mar;8(3):467-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10091649 10091649]

[[Category: Dihydrofolate reductase]]

[[Category: Lactobacillus casei]]

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[[Category: oxidoreductase]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:17:52 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1bzf.gif|left|200px]]<br /><applet load="1bzf" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1bzf.gif|left|200px]]
-caption="1bzf" />
-'''NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES'''<br />
+ {{Structure
+|PDB= 1bzf |SIZE=350|CAPTION= <scene name='initialview01'>1bzf</scene>
+|SITE= <scene name='pdbsite=TMQ:Residues+w.+Observed+Noes+To+Bound+Trimetrexate'>TMQ</scene>
+|LIGAND= <scene name='pdbligand=TMQ:TRIMETREXATE'>TMQ</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
+|GENE=
+}}
+'''NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-BZF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with <scene name='pdbligand=TMQ:'>TMQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Known structural/functional Site: <scene name='pdbsite=TMQ:Residues+w.+Observed+Noes+To+Bound+Trimetrexate'>TMQ</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BZF OCA].
+BZF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BZF OCA].
 ==Reference==
-Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate., Polshakov VI, Birdsall B, Frenkiel TA, Gargaro AR, Feeney J, Protein Sci. 1999 Mar;8(3):467-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10091649 10091649]
+Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate., Polshakov VI, Birdsall B, Frenkiel TA, Gargaro AR, Feeney J, Protein Sci. 1999 Mar;8(3):467-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10091649 10091649]
 [[Category: Dihydrofolate reductase]]
 [[Category: Lactobacillus casei]]
@@ Line 23: / Line 32: @@
 [[Category: oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:00:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:17:52 2008''