Hsp40: Difference between revisions
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Gauri Misra (talk | contribs) New page: =='Hsp40'== <StructureSection load='2QLD' size='340' side='right' caption='Human Hsp40 Hdj1' scene=''> Hsp40 ( J protein) and NEF cochaperones regulate the Hsp70 reaction cycle. The Hsp40... |
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<StructureSection load='2QLD' size='340' side='right' caption='Human Hsp40 Hdj1' scene=''> | <StructureSection load='2QLD' size='340' side='right' caption='Human Hsp40 Hdj1' scene=''> | ||
These proteins ( J protein) and NEF cochaperones regulate the Hsp70 reaction cycle. The Hsp40 proteins constitute a large family with more than 40 members in | |||
humans. All of them contain a J domain, which binds to the N-terminal ATPase domain of Hsp70 and the adjacent linker region. Canonical Hsp40s (members of classes I and II) function as chaperones independently and recruit Hsp70 to nonnative substrate proteins. Other Hsp40s (class III) are more diverse | humans. All of them contain a J domain, which binds to the N-terminal ATPase domain of Hsp70 and the adjacent linker region. Canonical Hsp40s (members of classes I and II) function as chaperones independently and recruit Hsp70 to nonnative substrate proteins. Other Hsp40s (class III) are more diverse | ||
and combine the J domain with a variety of functional modules. The interaction with Hsp70 strongly stimulates the hydrolysis of Hsp70-bound ATP to | and combine the J domain with a variety of functional modules. The interaction with Hsp70 strongly stimulates the hydrolysis of Hsp70-bound ATP to | ||
