1cqq: Difference between revisions

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[[Image:1cqq.gif|left|200px]]<br /><applet load="1cqq" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1cqq.gif|left|200px]]
caption="1cqq, resolution 1.85&Aring;" />
 
'''TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR'''<br />
{{Structure
|PDB= 1cqq |SIZE=350|CAPTION= <scene name='initialview01'>1cqq</scene>, resolution 1.85&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=AG7:4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER'>AG7</scene>
|ACTIVITY=
|GENE=
}}
 
'''TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1CQQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_2 Human rhinovirus 2] with <scene name='pdbligand=AG7:'>AG7</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQQ OCA].  
1CQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_2 Human rhinovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQQ OCA].  


==Reference==
==Reference==
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes., Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST, Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10500114 10500114]
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes., Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST, Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10500114 10500114]
[[Category: Human rhinovirus 2]]
[[Category: Human rhinovirus 2]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: viral protein]]
[[Category: viral protein]]


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