1csl: Difference between revisions
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[[Image:1csl.jpg|left|200px]] | [[Image:1csl.jpg|left|200px]] | ||
'''CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE''' | {{Structure | ||
|PDB= 1csl |SIZE=350|CAPTION= <scene name='initialview01'>1csl</scene>, resolution 1.60Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
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'''CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1CSL is a [ | 1CSL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA]. | ||
==Reference== | ==Reference== | ||
The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution., Ippolito JA, Steitz TA, J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:[http:// | The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution., Ippolito JA, Steitz TA, J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10656783 10656783] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Ippolito, J A.]] | [[Category: Ippolito, J A.]] | ||
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[[Category: rre high affinity site]] | [[Category: rre high affinity site]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:28:21 2008'' | ||
Revision as of 08:28, 20 March 2008
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| 1csl, resolution 1.60Å | |||||||||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE
Overview
The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies.
About this Structure
1CSL is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution., Ippolito JA, Steitz TA, J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:10656783
Page seeded by OCA on Thu Mar 20 10:28:21 2008
