4mh1: Difference between revisions

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'''Unreleased structure'''
==Crystal structure and functional studies of quinoprotein L-sorbose dehydrogenase from Ketogulonicigenium vulgare Y25==
<StructureSection load='4mh1' size='340' side='right' caption='[[4mh1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ketogulonicigenium_vulgare Ketogulonicigenium vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MH1 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene><br>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mh1 RCSB], [http://www.ebi.ac.uk/pdbsum/4mh1 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the L-sorbose dehydrogenase (SDH) from Ketogulonicigenium vulgare Y25 has been determined at 2.7 A resolution using the molecular replacement method. The overall structure of SDH is similar to that of other quinoprotein dehydrogenases; consisting of an eight bladed beta-propeller PQQ domain and protrusion loops. We identified a stable homodimer in crystal and demonstrated its existence in solution by sedimentation velocity measurement. By biochemical characterization of the SDH in vitro, using L-sorbose as substrate and cytochrome c551 as electron acceptor, we revealed cytochrome c551 acting as physiological primary electron acceptor for SDH.


The entry 4mh1 is ON HOLD  until Paper Publication
Crystal structure of L-sorbose dehydrogenase, a pyrroloquinoline quinone-dependent enzyme with homodimeric assembly, from Ketogulonicigenium vulgare.,Han X, Xiong X, Jiang D, Chen S, Huang E, Zhang W, Liu X Biotechnol Lett. 2014 May;36(5):1001-8. doi: 10.1007/s10529-013-1446-5. Epub 2014, Feb 21. PMID:24557074<ref>PMID:24557074</ref>


Authors: Han, X., Liu, X.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description: Crystal structure and functional studies of quinoprotein L-sorbose dehydrogenase from Ketogulonicigenium vulgare Y25
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ketogulonicigenium vulgare]]
[[Category: Han, X.]]
[[Category: Liu, X.]]
[[Category: 2-keto-l-gulonic acid]]
[[Category: Beta-propeller]]
[[Category: Carbohydrate/sugar binding]]
[[Category: Hydrolase]]
[[Category: Ketogulonicigenium vulgare]]
[[Category: L-sorbose dehydrogenase]]
[[Category: Oxidoreductase]]
[[Category: Periplasmic]]
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