4j1n: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structures of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold==

~~The entry~~ 4j1n is ~~ON HOLD until Jul 23 2015~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4j1n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1N OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1N FirstGlance].

~~Authors~~: ~~Mehboob~~, S., Boci, T., Brubaker, L., Santarsiero, B.D.~~, Johnson, M.E.~~

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=1JN:1-(4-METHOXY-3-METHYLBENZYL)-1,5,6,7-TETRAHYDROINDENO[5,6-D]IMIDAZOLE'>1JN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>

<tr><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[3uic|3uic]], [[4j3f|4j3f]], [[4j4t|4j4t]]</td></tr>

~~Description~~: ~~Crystal structures of FabI from F. tularensis in~~ complex ~~with novel inhibitors based on the benzimidazole scaffold~~

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </td></tr>

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j1n RCSB], [http://www.ebi.ac.uk/pdbsum/4j1n PDBsum]</td></tr>

<table>

__TOC__

</StructureSection>

[[Category: Boci, T.]]

[[Category: Brubaker, L.]]

[[Category: Johnson, M E.]]

[[Category: Mehboob, S.]]

[[Category: Santarsiero, B D.]]

[[Category: Nadh]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

[[Category: Reductase]]

[[Category: Reduction]]

[[Category: Rossman fold]]

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-'''Unreleased structure'''
+==Crystal structures of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold==
+<StructureSection load='4j1n' size='340' side='right' caption='[[4j1n]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-The entry 4j1n is ON HOLD  until Jul 23 2015
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4j1n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1N FirstGlance]. <br>
-Authors: Mehboob, S., Boci, T., Brubaker, L., Santarsiero, B.D., Johnson, M.E.
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JN:1-(4-METHOXY-3-METHYLBENZYL)-1,5,6,7-TETRAHYDROINDENO[5,6-D]IMIDAZOLE'>1JN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uic|3uic]], [[4j3f|4j3f]], [[4j4t|4j4t]]</td></tr>
-Description: Crystal structures of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j1n RCSB], [http://www.ebi.ac.uk/pdbsum/4j1n PDBsum]</span></td></tr>
+<table>
+__TOC__
+</StructureSection>
+[[Category: Boci, T.]]
+[[Category: Brubaker, L.]]
+[[Category: Johnson, M E.]]
+[[Category: Mehboob, S.]]
+[[Category: Santarsiero, B D.]]
+[[Category: Nadh]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+[[Category: Reductase]]
+[[Category: Reduction]]
+[[Category: Rossman fold]]