4lnr: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==The structure of HLA-B*35:01 in complex with the peptide (RPQVPLRPMTY)==

The ~~entry 4lnr~~ is ~~ON HOLD~~ ~~until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4lnr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LNR FirstGlance]. <br>

~~Authors~~: Cheng, H., ~~Shi, Y~~., Qi, J., ~~Gao, G.F~~.

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lnr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lnr RCSB], [http://www.ebi.ac.uk/pdbsum/4lnr PDBsum]</span></td></tr>

<table>

~~Description~~: ~~The structure of HLA-B*35~~:~~01 in complex with the peptide (RPQVPLRPMTY)~~

== Disease ==

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>

== Function ==

[[http://www.uniprot.org/uniprot/1B35_HUMAN 1B35_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

== References ==

__TOC__

</StructureSection>

[[Category: Cheng, H.]]

[[Category: Gao, G F.]]

[[Category: Qi, J.]]

[[Category: Shi, Y.]]

[[Category: Heterotrimer]]

[[Category: Immune system]]

[[Category: Ligand for t cell receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The structure of HLA-B*35:01 in complex with the peptide (RPQVPLRPMTY)==
+<StructureSection load='4lnr' size='340' side='right' caption='[[4lnr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-The entry 4lnr is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4lnr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LNR FirstGlance]. <br>
-Authors: Cheng, H., Shi, Y., Qi, J., Gao, G.F.
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lnr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lnr RCSB], [http://www.ebi.ac.uk/pdbsum/4lnr PDBsum]</span></td></tr>
+<table>
-Description: The structure of HLA-B*35:01 in complex with the peptide (RPQVPLRPMTY)
+== Disease ==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/1B35_HUMAN 1B35_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cheng, H.]]
+[[Category: Gao, G F.]]
+[[Category: Qi, J.]]
+[[Category: Shi, Y.]]
+[[Category: Heterotrimer]]
+[[Category: Immune system]]
+[[Category: Ligand for t cell receptor]]