4qtd: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode==

~~The entry~~ 4qtd is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4qtd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QTD OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QTD FirstGlance].

~~Authors~~: ~~Chaikuad~~, A., ~~Keates~~, T., ~~von Delft~~, F., ~~Arrowsmith~~, C.H., Edwards, A.M., ~~Bountra, C~~., Knapp, S., Structural Genomics Consortium ~~(SGC)~~

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=38Z:(3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL)PHENYL]PIPERAZIN-1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5-YL]PYRROLIDINE-3-CARBOXAMIDE'>38Z</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>

~~Description~~: ~~Structure of human JNK1 in~~ complex ~~with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode~~

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </td></tr>

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qtd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qtd RCSB], [http://www.ebi.ac.uk/pdbsum/4qtd PDBsum]</td></tr>

<table>

__TOC__

</StructureSection>

[[Category: Mitogen-activated protein kinase]]

[[Category: Arrowsmith, C H.]]

[[Category: Bountra, C.]]

[[Category: Chaikuad, A.]]

[[Category: Delft, F von.]]

[[Category: Edwards, A M.]]

[[Category: Keates, T.]]

[[Category: Knapp, S.]]

[[Category: SGC, Structural Genomics Consortium.]]

[[Category: Allosteric]]

[[Category: Inhibitor]]

[[Category: Kinase]]

[[Category: Mapk]]

[[Category: Sgc]]

[[Category: Signalling]]

[[Category: Structural genomic]]

[[Category: Structural genomics consortium]]

[[Category: Transferase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode==
+<StructureSection load='4qtd' size='340' side='right' caption='[[4qtd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-The entry 4qtd is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4qtd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QTD FirstGlance]. <br>
-Authors: Chaikuad, A., Keates, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38Z:(3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL)PHENYL]PIPERAZIN-1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5-YL]PYRROLIDINE-3-CARBOXAMIDE'>38Z</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qta|4qta]], [[4qtb|4qtb]], [[4qtc|4qtc]], [[4qte|4qte]]</td></tr>
-Description: Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qtd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qtd RCSB], [http://www.ebi.ac.uk/pdbsum/4qtd PDBsum]</span></td></tr>
+<table>
+__TOC__
+</StructureSection>
+[[Category: Mitogen-activated protein kinase]]
+[[Category: Arrowsmith, C H.]]
+[[Category: Bountra, C.]]
+[[Category: Chaikuad, A.]]
+[[Category: Delft, F von.]]
+[[Category: Edwards, A M.]]
+[[Category: Keates, T.]]
+[[Category: Knapp, S.]]
+[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Allosteric]]
+[[Category: Inhibitor]]
+[[Category: Kinase]]
+[[Category: Mapk]]
+[[Category: Sgc]]
+[[Category: Signalling]]
+[[Category: Structural genomic]]
+[[Category: Structural genomics consortium]]
+[[Category: Transferase]]
+[[Category: Transferase-transferase inhibitor complex]]