192d: Difference between revisions

Line 1:

[[~~Image~~:192d.~~png|left|200px~~]]

==RECOMBINATION-LIKE STRUCTURE OF D(CCGCGG)==

== Structural highlights ==

<table><tr><td colspan='2'>[[192d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=192D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=192D FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=192d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=192d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=192d RCSB], [http://www.ebi.ac.uk/pdbsum/192d PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

We have solved the single crystal X-ray structure of the synthetic DNA hexamer d(CCGCGG). The central alternating tetramer forms a Z-DNA duplex. The initial cytosine of each strand of the duplex swings out and forms a Watson-Crick base-pair with the terminal guanine of a symmetry-related molecule. Thus, two symmetry-related DNA molecules form a twin with intermolecular base-pairs at both ends. Such a twin is additionally stabilized by a sodium ion located on a dyad axis between two DNA duplexes. The total structure has recombination-like features. It also provides a model for B/Z junctions. The crystal used in this study belongs to space group C222(1) with a = 34.33 A, b = 44.04 A and c = 38.27 A. The structure was solved by molecular replacement using partial models, and refined by molecular dynamics simulated annealing and positional treatment. The refinement has been concluded with an R-factor of 18.5% for 2377 reflections with F > or = 2 sigma (F) in the resolution region 8.0 to 1.92 A. The asymmetric unit contains two strands of d(CCGCGG) and 38 water molecules.

~~{{STRUCTURE_192d| PDB=192d | SCENE= }}~~

Recombination-like structure of d(CCGCGG).,Malinina L, Urpi L, Salas X, Huynh-Dinh T, Subirana JA J Mol Biol. 1994 Oct 28;243(3):484-93. PMID:7966274<ref>PMID:7966274</ref>

~~===RECOMBINATION-LIKE STRUCTURE OF D(CCGCGG)===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_7966274}}~~

== References ==

==~~About this Structure~~==

__TOC__

~~[[192d]] is a 2 chain structure. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=192D OCA].~~

</StructureSection>

[[Category: Huynh-Dinh, T.]]

[[Category: Malinina, L.]]

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@@ Line 1: / Line 1: @@
-[[Image:192d.png|left|200px]]
+==RECOMBINATION-LIKE STRUCTURE OF D(CCGCGG)==
+<StructureSection load='192d' size='340' side='right' caption='[[192d]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[192d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=192D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=192D FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=192d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=192d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=192d RCSB], [http://www.ebi.ac.uk/pdbsum/192d PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We have solved the single crystal X-ray structure of the synthetic DNA hexamer d(CCGCGG). The central alternating tetramer forms a Z-DNA duplex. The initial cytosine of each strand of the duplex swings out and forms a Watson-Crick base-pair with the terminal guanine of a symmetry-related molecule. Thus, two symmetry-related DNA molecules form a twin with intermolecular base-pairs at both ends. Such a twin is additionally stabilized by a sodium ion located on a dyad axis between two DNA duplexes. The total structure has recombination-like features. It also provides a model for B/Z junctions. The crystal used in this study belongs to space group C222(1) with a = 34.33 A, b = 44.04 A and c = 38.27 A. The structure was solved by molecular replacement using partial models, and refined by molecular dynamics simulated annealing and positional treatment. The refinement has been concluded with an R-factor of 18.5% for 2377 reflections with F &gt; or = 2 sigma (F) in the resolution region 8.0 to 1.92 A. The asymmetric unit contains two strands of d(CCGCGG) and 38 water molecules.
-{{STRUCTURE_192d|  PDB=192d  |  SCENE=  }}
+Recombination-like structure of d(CCGCGG).,Malinina L, Urpi L, Salas X, Huynh-Dinh T, Subirana JA J Mol Biol. 1994 Oct 28;243(3):484-93. PMID:7966274<ref>PMID:7966274</ref>
-===RECOMBINATION-LIKE STRUCTURE OF D(CCGCGG)===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_7966274}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[192d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=192D OCA].
+</StructureSection>
 [[Category: Huynh-Dinh, T.]]
 [[Category: Malinina, L.]]