1a58: Difference between revisions

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[[Image:1a58.png|left|200px]]
==CYCLOPHILIN FROM BRUGIA MALAYI==
<StructureSection load='1a58' size='340' side='right' caption='[[1a58]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1a58]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A58 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6279 Brugia malayi])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a58 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a58 RCSB], [http://www.ebi.ac.uk/pdbsum/1a58 PDBsum]</span></td></tr>
<table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/1a58_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.


{{STRUCTURE_1a58|  PDB=1a58  |  SCENE=  }}
The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi.,Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:9559680<ref>PMID:9559680</ref>


===CYCLOPHILIN FROM BRUGIA MALAYI===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_9559680}}
 
==About this Structure==
[[1a58]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA].


==See Also==
==See Also==
*[[Cyclophilin|Cyclophilin]]
*[[Cyclophilin|Cyclophilin]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:009559680</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Brugia malayi]]
[[Category: Brugia malayi]]
[[Category: Husi, H.]]
[[Category: Husi, H.]]
Retrieved from "https://proteopedia.org/1a58"