3t15: Difference between revisions

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[[Image:3t15.png|left|200px]]
==Structure of green-type Rubisco activase from tobacco==
<StructureSection load='3t15' size='340' side='right' caption='[[3t15]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3t15]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_tobacco American tobacco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T15 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T15 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zw6|3zw6]]</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rca1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4097 American tobacco])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t15 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t15 RCSB], [http://www.ebi.ac.uk/pdbsum/3t15 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Rubisco, the enzyme that catalyzes the fixation of atmospheric CO(2) in photosynthesis, is subject to inactivation by inhibitory sugar phosphates. Here we report the 2.95-A crystal structure of Nicotiana tabacum Rubisco activase (Rca), the enzyme that facilitates the removal of these inhibitors. Rca from tobacco has a classical AAA(+)-protein domain architecture. Although Rca populates a range of oligomeric states when in solution, it forms a helical arrangement with six subunits per turn when in the crystal. However, negative-stain electron microscopy of the active mutant R294V suggests that Rca functions as a hexamer. The residues determining species specificity for Rubisco are located in a helical insertion of the C-terminal domain and probably function in conjunction with the N-domain in Rubisco recognition. Loop segments exposed toward the central pore of the hexamer are required for the ATP-dependent remodeling of Rubisco, resulting in the release of inhibitory sugar.


{{STRUCTURE_3t15|  PDB=3t15  |  SCENE=  }}
Structure of green-type Rubisco activase from tobacco.,Stotz M, Mueller-Cajar O, Ciniawsky S, Wendler P, Hartl FU, Bracher A, Hayer-Hartl M Nat Struct Mol Biol. 2011 Nov 6. doi: 10.1038/nsmb.2171. PMID:22056769<ref>PMID:22056769</ref>


===Structure of green-type Rubisco activase from tobacco===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_22056769}}
 
==About this Structure==
[[3t15]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T15 OCA].


==See Also==
==See Also==
*[[RuBisCO|RuBisCO]]
*[[RuBisCO|RuBisCO]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022056769</ref><references group="xtra"/>
__TOC__
[[Category: Nicotiana tabacum]]
</StructureSection>
[[Category: American tobacco]]
[[Category: Bracher, A.]]
[[Category: Bracher, A.]]
[[Category: Hartl, F U.]]
[[Category: Hartl, F U.]]
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