1d6n: Difference between revisions

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[[Image:1d6n.jpg|left|200px]]<br /><applet load="1d6n" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1d6n.jpg|left|200px]]
caption="1d6n, resolution 2.70&Aring;" />
 
'''TERNARY COMPLEX STRUCTURE OF HUMAN HGPRTASE, PRPP, MG2+, AND THE INHIBITOR HPP REVEALS THE INVOLVEMENT OF THE FLEXIBLE LOOP IN SUBSTRATE BINDING'''<br />
{{Structure
|PDB= 1d6n |SIZE=350|CAPTION= <scene name='initialview01'>1d6n</scene>, resolution 2.70&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPO:3H-PYRAZOLO[4,3-D]PYRIMIDIN-7-OL'>PPO</scene> and <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID'>PRP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8]
|GENE=
}}
 
'''TERNARY COMPLEX STRUCTURE OF HUMAN HGPRTASE, PRPP, MG2+, AND THE INHIBITOR HPP REVEALS THE INVOLVEMENT OF THE FLEXIBLE LOOP IN SUBSTRATE BINDING'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1D6N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=PPO:'>PPO</scene> and <scene name='pdbligand=PRP:'>PRP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6N OCA].  
1D6N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6N OCA].  


==Reference==
==Reference==
Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding., Balendiran GK, Molina JA, Xu Y, Torres-Martinez J, Stevens R, Focia PJ, Eakin AE, Sacchettini JC, Craig SP 3rd, Protein Sci. 1999 May;8(5):1023-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10338013 10338013]
Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding., Balendiran GK, Molina JA, Xu Y, Torres-Martinez J, Stevens R, Focia PJ, Eakin AE, Sacchettini JC, Craig SP 3rd, Protein Sci. 1999 May;8(5):1023-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10338013 10338013]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hypoxanthine phosphoribosyltransferase]]
[[Category: Hypoxanthine phosphoribosyltransferase]]
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[[Category: hgprtase]]
[[Category: hgprtase]]


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