4d08: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==PDE2a catalytic domain in complex with a brain penetrant inhibitor==

~~The entry~~ 4d08 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4d08]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D08 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D08 FirstGlance].

~~Authors~~: ~~Buijnsters~~, P., Andres, J.I., DeAngelis, M., Langlois, X., Rombouts, F., Sanderson, W., Tresadern, G.~~, Trabanco, A.,~~ VanHoof, G., VanRoosbroeck, Y.

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Q2T:1-(5-BUTOXYPYRIDIN-3-YL)-4-METHYL-8-(MORPHOLIN-4-YLMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE'>Q2T</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>

<tr><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4d09|4d09]]</td></tr>

~~Description~~: ~~PDE2a catalytic~~ domain ~~in complex with a brain penetrant~~ inhibitor

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </td></tr>

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d08 RCSB], [http://www.ebi.ac.uk/pdbsum/4d08 PDBsum]</td></tr>

<table>

__TOC__

</StructureSection>

[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]

[[Category: Andres, J I.]]

[[Category: Buijnsters, P.]]

[[Category: DeAngelis, M.]]

[[Category: Langlois, X.]]

[[Category: Rombouts, F.]]

[[Category: Sanderson, W.]]

[[Category: Trabanco, A.]]

[[Category: Tresadern, G.]]

[[Category: VanHoof, G.]]

[[Category: VanRoosbroeck, Y.]]

[[Category: Animal]]

[[Category: Binding site]]

[[Category: Catalytic domain]]

[[Category: Cyclic nucleotide phosphodiesterase]]

[[Category: Disease model]]

[[Category: Drug evaluation]]

[[Category: Hydrolase]]

[[Category: Phosphodiesterase 2 inhibitor]]

[[Category: Phosphodiesterase inhibitor]]

[[Category: Preclinical]]

[[Category: Protein binding]]

[[Category: Structure-activity relationship]]

[[Category: Type 2]]

[[Category: Type 4]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==PDE2a catalytic domain in complex with a brain penetrant inhibitor==
+<StructureSection load='4d08' size='340' side='right' caption='[[4d08]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-The entry 4d08 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4d08]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D08 FirstGlance]. <br>
-Authors: Buijnsters, P., Andres, J.I., DeAngelis, M., Langlois, X., Rombouts, F., Sanderson, W., Tresadern, G., Trabanco, A., VanHoof, G., VanRoosbroeck, Y.
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Q2T:1-(5-BUTOXYPYRIDIN-3-YL)-4-METHYL-8-(MORPHOLIN-4-YLMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE'>Q2T</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d09|4d09]]</td></tr>
-Description: PDE2a catalytic domain in complex with a brain penetrant inhibitor
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d08 RCSB], [http://www.ebi.ac.uk/pdbsum/4d08 PDBsum]</span></td></tr>
+<table>
+__TOC__
+</StructureSection>
+[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
+[[Category: Andres, J I.]]
+[[Category: Buijnsters, P.]]
+[[Category: DeAngelis, M.]]
+[[Category: Langlois, X.]]
+[[Category: Rombouts, F.]]
+[[Category: Sanderson, W.]]
+[[Category: Trabanco, A.]]
+[[Category: Tresadern, G.]]
+[[Category: VanHoof, G.]]
+[[Category: VanRoosbroeck, Y.]]
+[[Category: Animal]]
+[[Category: Binding site]]
+[[Category: Catalytic domain]]
+[[Category: Cyclic nucleotide phosphodiesterase]]
+[[Category: Disease model]]
+[[Category: Drug evaluation]]
+[[Category: Hydrolase]]
+[[Category: Phosphodiesterase 2 inhibitor]]
+[[Category: Phosphodiesterase inhibitor]]
+[[Category: Preclinical]]
+[[Category: Protein binding]]
+[[Category: Structure-activity relationship]]
+[[Category: Type 2]]
+[[Category: Type 4]]