1ddu: Difference between revisions

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[[Image:1ddu.gif|left|200px]]<br /><applet load="1ddu" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ddu.gif|left|200px]]
caption="1ddu, resolution 2.1&Aring;" />
 
'''E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2',5'-DIDEOXYURIDINE (DDURD)'''<br />
{{Structure
|PDB= 1ddu |SIZE=350|CAPTION= <scene name='initialview01'>1ddu</scene>, resolution 2.1&Aring;
|SITE= <scene name='pdbsite=ACT:Active+Site+Reactive+Thiol'>ACT</scene>
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=DDU:2'-5'DIDEOXYURIDINE'>DDU</scene> and <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC ACID'>CB3</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE= THYA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2',5'-DIDEOXYURIDINE (DDURD)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1DDU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=DDU:'>DDU</scene> and <scene name='pdbligand=CB3:'>CB3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Known structural/functional Site: <scene name='pdbsite=ACT:Active+Site+Reactive+Thiol'>ACT</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDU OCA].  
1DDU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDU OCA].  


==Reference==
==Reference==
The additivity of substrate fragments in enzyme-ligand binding., Stout TJ, Sage CR, Stroud RM, Structure. 1998 Jul 15;6(7):839-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9687366 9687366]
The additivity of substrate fragments in enzyme-ligand binding., Stout TJ, Sage CR, Stroud RM, Structure. 1998 Jul 15;6(7):839-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9687366 9687366]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: DDU]]
[[Category: DDU]]
[[Category: PO4]]
[[Category: PO4]]
[[Category: substrate modules]]
[[Category: substrate module]]
[[Category: transferase (methyltransferase)]]
[[Category: transferase (methyltransferase)]]


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