CHEM2052 Tutorial Example4: Difference between revisions

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== '''Chem2052: Example 4 - Renin''' ==
== '''Chem2052: Example 4 - Renin''' ==


The spinning structure you initially view on this page is an enzyme called Renin. Renin is an '''aspartyl protease''', like other proteases Renin cleaves peptides.
The spinning structure you initially view on this page is a protease called Renin. Renin is an '''aspartyl protease''', which cleaves a particular peptide called angiotensinogen.


== Background ==
== Background ==
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== '''Active Sites''' ==
== '''Active Sites''' ==


This representation illustrates the active site catalytic residues of Renin.
This representation illustrates the <scene name='59/596437/Renin_catalytic_residues/2'>active site catalytic residues</scene> of Renin.
<scene name='55/559112/Renin_catalytic_residues/1'>Renin Catalytic Residues</scene>
 
== '''Inhibition of Renin''' ==
This scene shows the <scene name='55/559112/active site of renin with the Pfizer inhibitor bound/1'>Renin Catalytic Residues</scene>. Which part of the inhibibtor binds to the catalytic residues of the active site?
 
<scene name='55/559112/Renin_catalytic_residues/1'>Renin Catalytic Residues</scene>
<scene name='55/559112/Renin_catalytic_residues/1'>Renin Catalytic Residues</scene>