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{{STRUCTURE_1l2q|  PDB=1l2q  |  SCENE=  }}
==Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)==
===Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)===
<StructureSection load='1l2q' size='340' side='right' caption='[[1l2q]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
{{ABSTRACT_PUBMED_12029132}}
== Structural highlights ==
<table><tr><td colspan='2'>[[1l2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2Q FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene><br>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=XPL:N~6~-[(3R,5R)-5-AMINO-3-METHYL-D-PROLYL]-L-LYSINE'>XPL</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l2r|1l2r]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l2q RCSB], [http://www.ebi.ac.uk/pdbsum/1l2q PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.


==About this Structure==
A new UAG-encoded residue in the structure of a methanogen methyltransferase.,Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK Science. 2002 May 24;296(5572):1462-6. PMID:12029132<ref>PMID:12029132</ref>
[[1l2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Q OCA].
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


==See Also==
==See Also==
*[[Pyrrolysine|Pyrrolysine]]
*[[Pyrrolysine|Pyrrolysine]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:012029132</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Methanosarcina barkeri]]
[[Category: Methanosarcina barkeri]]
[[Category: Chan, M K.]]
[[Category: Chan, M K.]]
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