CHEM2052 Tutorial Example4: Difference between revisions
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== '''Active Site''' == | == '''Active Site''' == | ||
This representation illustrates the <scene name='59/596437/Renin_catalytic_residues/2'>active site catalytic residues</scene> of Renin. Consider the mechanism of the enzymatic cleavage of the natural peptide substrate angiotensinase. Identify the structure of the transition state. In later lectures we will see how knowledge of the transition state can be used to design very effective enzyme inhibitors called "transition state" inhibitors. | This representation illustrates the <scene name='59/596437/Renin_catalytic_residues/2'>active site catalytic residues</scene> of Renin. Consider the mechanism of the enzymatic cleavage of the natural peptide substrate angiotensinase. Identify the structure of the transition state. In later lectures we will see how knowledge of the transition state can be used to design very effective enzyme inhibitors which mimic this transition state these are (not surprisingly) called "transition state" inhibitors. | ||
== '''Inhibition of Renin''' == | == '''Inhibition of Renin''' == | ||
