CHEM2052 Tutorial Example4: Difference between revisions

This representation illustrates the <scene name='59/596437/Renin_catalytic_residues/2'>active site catalytic residues</scene> of Renin. Consider the mechanism of the enzymatic cleavage of the natural peptide substrate angiotensinase. Identify the structure of the transition state. In later lectures we will see how knowledge of this transition state can be used to design very effective enzyme inhibitors which mimic this structure, as you will find out, these are (not surprisingly) called "transition state" inhibitors. But for now though we will focus on the Pfizer inhibitor.