CHEM2052 Tutorial Example4: Difference between revisions

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 == '''Active Site Interactions''' ==
-Once you have thought about the types of interactions you would expect this inhibitor COULD make at the active site of the enzyme (refer to your notes for an example)then look at the 2-dimensional "map" of the active site on your tutorial sheet and compare this to the 3-dimensional representations here.
+This inhibitor does not just bind to the catalytic residues there are many other amino acids at the active site of the enzyme. First predict possible interaction types you would expect with this structure. Then look at the 2-dimensional "map" of the active site provided on your tutorial sheet and compare this to the 3-dimensional representations here.
-This view shows the amino acid residues on the left hand side of your "map".
+This view shows the amino acid residues on the left hand side of your "map". You may notice that these amino acids are fairly hydrophobic and interact with the hydrophobic parts of the inhibitor.
-This view shows the amino acid residues on the right hand side of your "map".
+Similarly this view shows the amino acid residues on the right hand side of your "map".
 == Structural highlights ==

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