Factor IX: Difference between revisions

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Michal Harel (talk | contribs)
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  {{STRUCTURE_3lc3|  PDB=3lc3  | SIZE=400| SCENE= |right|  CAPTION=Pig factor IX residues 8-147 (aqua) and 183-409 (pink) complex with tripeptide, [[1pfx]] }}
  {{STRUCTURE_3lc3|  PDB=3lc3  | SIZE=400| SCENE= |right|  CAPTION=Human factor IX heavy chain (grey and pink) and light chain (green and yellow) complex with inhibitor and Ca+2 ion (green), (PDB code [[3lc3]]) }}


<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> (plasma thromboplastin component, Christmas factor, or hemophilia B factor) is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.   
<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> (plasma thromboplastin component, Christmas factor, or hemophilia B factor) is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.   
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