NF-kB

<StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry 1nfk)' scene=>

NF-kB or Nuclear Factor NF-kappa is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: NF-kB1 (synthesized as p105 and processed to p50), NF-kB2 (synthesized as p100 and processed to p52), RelA (or p65), RelB and cRel. I-κ-B-α is an inhibitor of NF-kB.

3D structures of NF-kappaB

Updated on 19-August-2014

RelA (p65)

1bft, 1my5 – mRelA dimerization domain – mouse
1my7 – mRelA dimerization domain (mutant)
1ram, 2ram – mRelA residues 19-291 + DNA
1k3z, 1oy3 – mRelA dimerization domain + I-κ-B-α

NF-kB1 (p50)

1svc – hp50 + DNA - human - NMR
1nfk – mp50 + DNA
1bfs – mp50 dimerization domain
1u36, 1u3j, 1u3y, 1u3z, 1u41, 1u42 – mp50 dimerization domain (mutant)

NF-kB1 (p105)

2dbf – hp105 death domain
1ooa – mp105 + RNA

NF-kB1 + RelA

1nfi – hp50 + RelA + I-κ-B-α
1ikn – mp50 + RelA + I-κ-B-α
1vkx, 1le5, 1le9, 1lei – mp50 + RelA + DNA
2i9t – mp105 + RelA + DNA
2v2t – mp50 + RelB + DNA
2o61 – hp105 RHR domain + RelA + DNA
3gut – hp105 + RelA + DNA
3jv4 – hp105 dimerization domain + RelB dimerization domain

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Michal Harel, Alexander Berchansky