SAGA-associated factor: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='3mhs' size='350' side='right' caption='Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow) and UB8P (grey) (PDB entry [[3mhs]])' scene=''> | <StructureSection load='3mhs' size='350' side='right' caption='Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow) and UB8P (grey) (PDB entry [[3mhs]])' scene=''> | ||
'''SAGA-associated factor''' (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes. SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation. SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level. | '''SAGA-associated factor''' (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes.<br /> | ||
* '''SGF29''' binds methylated lysine of histone H3 and is involved in transcriptional regulation.<br /> | |||
* '''SGF11''' is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level. | |||
==3D structures of SAGA-associated factor== | ==3D structures of SAGA-associated factor== | ||
Revision as of 08:56, 20 August 2014
<StructureSection load='3mhs' size='350' side='right' caption='Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow) and UB8P (grey) (PDB entry 3mhs)' scene=>
SAGA-associated factor (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes.
- SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation.
- SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level.
3D structures of SAGA-associated factor
Updated on 20-August-2014
SGF11
2lo2 – ySGF zinc finger domain – yeast – NMR
3kik, 3kjl – ySGF Sus1-binding domain + Sus1
3mhh, 3m99, 4fip, 4fjc, 4fk5 – yUBP8 + Sus1 +SGF73 - yeast
3mhs – yUBP8 + Sus1 +SGF73 + ubiquitin
SGF29
3me9, 3mea, 3met, 3meu, 3mev, 3mew, 3mp1, 3mp6 – hSGF tudor domain + histone H3 peptide – human
3lx7, 3mp8 - hSGF tudor domain
SGF73
2lo3 – ySGF zinc finger domain – NMR
