Sentrin-specific protease: Difference between revisions
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
===Senp1=== | |||
[[2ckg]], [[2iyc]] – hSenp1 C terminal – human<br /> | [[2ckg]], [[2iyc]] – hSenp1 C terminal – human<br /> | ||
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[[2iy0]] – hSenp1 C terminal + SUMO1 + RanGAP C terminal<br /> | [[2iy0]] – hSenp1 C terminal + SUMO1 + RanGAP C terminal<br /> | ||
===Senp2=== | |||
[[1tgz]] – hSenp2 catalytic domain + SUMO1<br /> | [[1tgz]] – hSenp2 catalytic domain + SUMO1<br /> | ||
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[[2io2]] – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal<br /> | [[2io2]] – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal<br /> | ||
===Senp7=== | |||
[[3eay]] – hSenp7 catalytic domain + SUMO1<br /> | [[3eay]] – hSenp7 catalytic domain + SUMO1<br /> | ||
===Senp8=== | |||
[[1xt9]], [[2bkr]] – hSenp8 + Nedd8<br /> | [[1xt9]], [[2bkr]] – hSenp8 + Nedd8<br /> | ||
[[2bkq]] – hSenp8 <br /> | [[2bkq]] – hSenp8 <br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:28, 20 August 2014
<StructureSection load='2iy0' size='350' side='right' caption='Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry 2iy0)' scene=>
Sentrin-specific protease 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide.
3D structures of sentrin-specific protease
Updated on 20-August-2014
Senp1
2ckg, 2iyc – hSenp1 C terminal – human
2xph, 2xre – hSenp1 C terminal + Co
2ckh, 2iyd – hSenp1 C terminal + SUMO2
2iy1, 2g4d – hSenp1 C terminal (mutant) + SUMO1
2iy0 – hSenp1 C terminal + SUMO1 + RanGAP C terminal
Senp2
1tgz – hSenp2 catalytic domain + SUMO1
1th0 – hSenp2 catalytic domain
2io0 – hSenp2 catalytic domain (mutant) + SUMO1 precursor
3zo5 - hSenp2 catalytic domain (mutant) + SUMO2 precursor
2io1 – hSenp2 catalytic domain (mutant) + SUMO3 precursor
2io3 – hSenp2 catalytic domain (mutant) + SUMO2 + RanGAP C terminal
2io2 – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal
Senp7
3eay – hSenp7 catalytic domain + SUMO1
