1c4e: Difference between revisions

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[[Image:1c4e.png|left|200px]]
==GURMARIN FROM GYMNEMA SYLVESTRE==
<StructureSection load='1c4e' size='340' side='right' caption='[[1c4e]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C4E FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gur|2gur]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Gurmarin is a 35-residue polypeptide from the Asclepiad vine Gymnema sylvestre. It has been utilised as a pharmacological tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet tastants in rats. We have chemically synthesised and folded gurmarin and determined its three-dimensional solution structure to high resolution using two-dimensional NMR spectroscopy. Structure calculations utilised 612 interproton-distance, 19 dihedral-angle, and 18 hydrogen-bond restraints. The structure is well defined for residues 3-34, with backbone and heavy atom rms differences of 0.27 +/- 0.09 A and 0.73 +/- 0.09 A, respectively. Gurmarin adopts a compact structure containing an antiparallel beta-hairpin (residues 22-34), several well-defined beta-turns, and a cystine-knot motif commonly observed in toxic and inhibitory polypeptides. Despite striking structural homology with delta-atracotoxin, a spider neurotoxin known to slow the inactivation of voltage-gated Na+ channels, we show that gurmarin has no effect on a variety of voltage-sensitive channels.


{{STRUCTURE_1c4e|  PDB=1c4e  |  SCENE=  }}
High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide.,Fletcher JI, Dingley AJ, Smith R, Connor M, Christie MJ, King GF Eur J Biochem. 1999 Sep;264(2):525-33. PMID:10491100<ref>PMID:10491100</ref>


===GURMARIN FROM GYMNEMA SYLVESTRE===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_10491100}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1c4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:010491100</ref><references group="xtra"/>
[[Category: Gymnema sylvestre]]
[[Category: Gymnema sylvestre]]
[[Category: Dingley, A J.]]
[[Category: Dingley, A J.]]
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