Aconitase: Difference between revisions
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The images at the left and at the right correspond to one representative Aconitase, ''i.e.'' the crystal structure of Bovine Aconitase ([[1amj]]). | The images at the left and at the right correspond to one representative Aconitase, ''i.e.'' the crystal structure of Bovine Aconitase ([[1amj]]). | ||
In most organisms, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria. | In most organisms, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria. | ||
Aconitase contains a Fe4S4 cluster which converts to Fe3S4 when the enzyme is inactive. In humans, two types of ACO are expressed: the soluble ACO1 and the mitochondrial ACO2. | Aconitase contains a Fe4S4 cluster which converts to Fe3S4 when the enzyme is inactive. In humans, two types of ACO are expressed: the soluble '''ACO1''' and the mitochondrial '''ACO2'''. | ||
Aconitase from pig (PDB [[7acn]]) is a single polypeptide (M<sub>r</sub> 83kD) that catalyzes the reversible isomerization of citrate and isocitrate.<ref name="Zheng">PMID 1313811</ref> It is the second enzyme in the Citric acid cycle, which is a series of enzyme-catalysed chemical reactions that is crucial to aerobic cellular respiration and the production of ATP. | Aconitase from pig (PDB [[7acn]]) is a single polypeptide (M<sub>r</sub> 83kD) that catalyzes the reversible isomerization of citrate and isocitrate.<ref name="Zheng">PMID 1313811</ref> It is the second enzyme in the Citric acid cycle, which is a series of enzyme-catalysed chemical reactions that is crucial to aerobic cellular respiration and the production of ATP. | ||
