4oji: Difference between revisions
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oji RCSB], [http://www.ebi.ac.uk/pdbsum/4oji PDBsum]</span></td></tr> | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oji RCSB], [http://www.ebi.ac.uk/pdbsum/4oji PDBsum]</span></td></tr> | ||
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== Publication Abstract from PubMed == | |||
We present a crystal structure at 2.3-A resolution of the recently described nucleolytic ribozyme twister. The RNA adopts a previously uncharacterized compact fold based on a double-pseudoknot structure, with the active site at its center. Eight highly conserved nucleobases stabilize the core of the ribozyme through the formation of one Watson-Crick and three noncanonical base pairs, and the highly conserved adenine 3' of the scissile phosphate is bound in the major groove of an adjacent pseudoknot. A strongly conserved guanine nucleobase directs its Watson-Crick edge toward the scissile phosphate in the crystal structure, and mechanistic evidence supports a role for this guanine as either a general base or acid in a concerted, general acid-base-catalyzed cleavage reaction. | |||
Crystal structure and mechanistic investigation of the twister ribozyme.,Liu Y, Wilson TJ, McPhee SA, Lilley DM Nat Chem Biol. 2014 Sep;10(9):739-44. doi: 10.1038/nchembio.1587. Epub 2014 Jul, 20. PMID:25038788<ref>PMID:25038788</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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== References == | |||
<references/> | |||
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</StructureSection> | </StructureSection> | ||
Revision as of 05:52, 27 August 2014
Crystal Structure of Twister Ribozyme
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