4q7j: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''
==Complex structure of viral RNA polymerase==
<StructureSection load='4q7j' size='340' side='right' caption='[[4q7j]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4q7j]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q7J FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3agp|3agp]], [[3agq|3agq]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q7j RCSB], [http://www.ebi.ac.uk/pdbsum/4q7j PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Ribosomal protein S1, consisting of six contiguous OB-folds, is the largest ribosomal protein and is essential for translation initiation in Escherichia coli. S1 is also one of the three essential host-derived subunits of Qbeta replicase, together with EF-Tu and EF-Ts, for Qbeta RNA replication in E. coli. We analyzed the crystal structure of Qbeta replicase, consisting of the virus-encoded RNA-dependent RNA polymerase (beta-subunit), EF-Tu, EF-Ts and the N-terminal half of S1, which is capable of initiating Qbeta RNA replication. Structural and biochemical studies revealed that the two N-terminal OB-folds of S1 anchor S1 onto the beta-subunit, and the third OB-fold is mobile and protrudes beyond the surface of the beta-subunit. The third OB-fold mainly interacts with a specific RNA fragment derived from the internal region of Qbeta RNA, and its RNA-binding ability is required for replication initiation of Qbeta RNA. Thus, the third mobile OB-fold of S1, which is spatially anchored near the surface of the beta-subunit, primarily recruits the Qbeta RNA toward the beta-subunit, leading to the specific and efficient replication initiation of Qbeta RNA, and S1 functions as a replication initiation factor, beyond its established function in protein synthesis.


The entry 4q7j is ON HOLD  until Paper Publication
Molecular insights into replication initiation by Qbeta replicase using ribosomal protein S1.,Takeshita D, Yamashita S, Tomita K Nucleic Acids Res. 2014 Aug 13. pii: gku745. PMID:25122749<ref>PMID:25122749</ref>


Authors: Takeshita, D.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description: Complex structure of viral RNA polymerase
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Takeshita, D.]]
[[Category: Rna binding motif]]
[[Category: Rna dependent rna polymerization]]
[[Category: Rna polymerase]]
[[Category: Translation-transferase complex]]
Retrieved from "https://proteopedia.org/4q7j"