4mzv: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Crystal structure of extracellular part of human EpCAM==

The entry ~~4mzv~~ is ~~ON HOLD~~ ~~until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZV FirstGlance].

~~Authors~~: ~~Pavsic, M~~., ~~Guncar, G~~., Djinovic-Carugo, K., Lenarcic, B.

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>

<tr><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>

~~Description~~: ~~Crystal structure of extracellular part of human EpCAM~~

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum]</td></tr>

<table>

== Disease ==

[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] Intestinal epithelial dysplasia;Hereditary nonpolyposis colon cancer. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:18572020</ref> The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.<ref>PMID:19098912</ref>

== Function ==

[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.<ref>PMID:15195135</ref> <ref>PMID:15922867</ref> <ref>PMID:20064925</ref> <ref>PMID:19785009</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Djinovic-Carugo, K.]]

[[Category: Guncar, G.]]

[[Category: Lenarcic, B.]]

[[Category: Pavsic, M.]]

[[Category: Cell adhesion]]

[[Category: Dimer]]

[[Category: Ectodomain]]

[[Category: Extracellular space]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of extracellular part of human EpCAM==
+<StructureSection load='4mzv' size='340' side='right' caption='[[4mzv]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
-The entry 4mzv is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZV FirstGlance]. <br>
-Authors: Pavsic, M., Guncar, G., Djinovic-Carugo, K., Lenarcic, B.
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene><br>
+<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-Description: Crystal structure of extracellular part of human EpCAM
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum]</span></td></tr>
+<table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] Intestinal epithelial dysplasia;Hereditary nonpolyposis colon cancer. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:18572020</ref>   The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.<ref>PMID:19098912</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.<ref>PMID:15195135</ref> <ref>PMID:15922867</ref> <ref>PMID:20064925</ref> <ref>PMID:19785009</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Djinovic-Carugo, K.]]
+[[Category: Guncar, G.]]
+[[Category: Lenarcic, B.]]
+[[Category: Pavsic, M.]]
+[[Category: Cell adhesion]]
+[[Category: Dimer]]
+[[Category: Ectodomain]]
+[[Category: Extracellular space]]