1dyj: Difference between revisions

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[[Image:1dyj.gif|left|200px]]~~<br /><applet load~~="1dyj~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1dyj.gif|left|200px]]

~~caption="~~1dyj, resolution 1.85Å" />

'''ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS'''~~<br />~~

{{Structure

|PDB= 1dyj |SIZE=350|CAPTION= <scene name='initialview01'>1dyj</scene>, resolution 1.85Å

|SITE=

|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=DDF:5,10-DIDEAZATETRAHYDROFOLIC ACID'>DDF</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]

|GENE=

}}

'''ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS'''

==Overview==

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==About this Structure==

1DYJ is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] ~~with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=DDF:'>DDF</scene> as [http://en.wikipedia~~.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DYJ OCA].

1DYJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DYJ OCA].

==Reference==

Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications., Reyes VM, Sawaya MR, Brown KA, Kraut J, Biochemistry. 1995 Feb 28;34(8):2710-23. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~7873554 7873554]

Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications., Reyes VM, Sawaya MR, Brown KA, Kraut J, Biochemistry. 1995 Feb 28;34(8):2710-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7873554 7873554]

[[Category: Dihydrofolate reductase]]

[[Category: Escherichia coli]]

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[[Category: oxidoreductase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 12~~:21:51 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:46:32 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1dyj.gif|left|200px]]<br /><applet load="1dyj" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1dyj.gif|left|200px]]
-caption="1dyj, resolution 1.85&Aring;" />
-'''ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS'''<br />
+ {{Structure
+|PDB= 1dyj |SIZE=350|CAPTION= <scene name='initialview01'>1dyj</scene>, resolution 1.85&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=DDF:5,10-DIDEAZATETRAHYDROFOLIC ACID'>DDF</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
+|GENE=
+}}
+'''ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-DYJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=DDF:'>DDF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DYJ OCA].
+DYJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DYJ OCA].
 ==Reference==
-Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications., Reyes VM, Sawaya MR, Brown KA, Kraut J, Biochemistry. 1995 Feb 28;34(8):2710-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7873554 7873554]
+Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications., Reyes VM, Sawaya MR, Brown KA, Kraut J, Biochemistry. 1995 Feb 28;34(8):2710-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7873554 7873554]
 [[Category: Dihydrofolate reductase]]
 [[Category: Escherichia coli]]
@@ Line 21: / Line 30: @@
 [[Category: oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:21:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:46:32 2008''