1e2l: Difference between revisions

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[[Image:1e2l.gif|left|200px]]<br /><applet load="1e2l" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1e2l.gif|left|200px]]
caption="1e2l, resolution 2.4&Aring;" />
 
'''KINETICS AND CRYSTAL STRUCTURE OF THE WILD-TYPE AND THE ENGINEERED Y101F MUTANT OF HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (NORTH)-METHANOCARBA-THYMIDINE'''<br />
{{Structure
|PDB= 1e2l |SIZE=350|CAPTION= <scene name='initialview01'>1e2l</scene>, resolution 2.4&Aring;
|SITE= <scene name='pdbsite=AC1:Tmc+Binding+Site+For+Chain+A'>AC1</scene> and <scene name='pdbsite=AC2:Tmc+Binding+Site+For+Chain+B'>AC2</scene>
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=TMC:1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>TMC</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21]
|GENE=
}}
 
'''KINETICS AND CRYSTAL STRUCTURE OF THE WILD-TYPE AND THE ENGINEERED Y101F MUTANT OF HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (NORTH)-METHANOCARBA-THYMIDINE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1E2L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=TMC:'>TMC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] Known structural/functional Sites: <scene name='pdbsite=AC1:Tmc+Binding+Site+For+Chain+A'>AC1</scene> and <scene name='pdbsite=AC2:Tmc+Binding+Site+For+Chain+B'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2L OCA].  
1E2L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2L OCA].  


==Reference==
==Reference==
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine., Prota A, Vogt J, Pilger B, Perozzo R, Wurth C, Marquez VE, Russ P, Schulz GE, Folkers G, Scapozza L, Biochemistry. 2000 Aug 8;39(31):9597-603. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10924157 10924157]
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine., Prota A, Vogt J, Pilger B, Perozzo R, Wurth C, Marquez VE, Russ P, Schulz GE, Folkers G, Scapozza L, Biochemistry. 2000 Aug 8;39(31):9597-603. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10924157 10924157]
[[Category: Human herpesvirus 4]]
[[Category: Human herpesvirus 4]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: x-ray structure]]
[[Category: x-ray structure]]


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