1e9n: Difference between revisions

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[[Image:1e9n.jpg|left|200px]]<br /><applet load="1e9n" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1e9n.jpg|left|200px]]
caption="1e9n, resolution 2.2&Aring;" />
 
'''A SECOND DIVALENT METAL ION IN THE ACTIVE SITE OF A NEW CRYSTAL FORM OF HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE, APE1, AND ITS IMPLICATIONS FOR THE CATALYTIC MECHANISM'''<br />
{{Structure
|PDB= 1e9n |SIZE=350|CAPTION= <scene name='initialview01'>1e9n</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=PB1:Pb+Binding+Site+For+Residue+A1319'>PB1</scene>, <scene name='pdbsite=PB2:Pb+Binding+Site+For+Residue+A1320'>PB2</scene>, <scene name='pdbsite=PB3:Pb+Binding+Site+For+Residue+B1319'>PB3</scene> and <scene name='pdbsite=PB4:Pb+Binding+Site+For+Residue+B1320'>PB4</scene>
|LIGAND= <scene name='pdbligand=PB:LEAD (II) ION'>PB</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA-(apurinic_or_apyrimidinic_site)_lyase DNA-(apurinic or apyrimidinic site) lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.99.18 4.2.99.18]
|GENE= APE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''A SECOND DIVALENT METAL ION IN THE ACTIVE SITE OF A NEW CRYSTAL FORM OF HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE, APE1, AND ITS IMPLICATIONS FOR THE CATALYTIC MECHANISM'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1E9N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PB:'>PB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/DNA-(apurinic_or_apyrimidinic_site)_lyase DNA-(apurinic or apyrimidinic site) lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.99.18 4.2.99.18] Known structural/functional Sites: <scene name='pdbsite=PB1:Pb+Binding+Site+For+Residue+A1319'>PB1</scene>, <scene name='pdbsite=PB2:Pb+Binding+Site+For+Residue+A1320'>PB2</scene>, <scene name='pdbsite=PB3:Pb+Binding+Site+For+Residue+B1319'>PB3</scene> and <scene name='pdbsite=PB4:Pb+Binding+Site+For+Residue+B1320'>PB4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9N OCA].  
1E9N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9N OCA].  


==Reference==
==Reference==
Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism., Beernink PT, Segelke BW, Hadi MZ, Erzberger JP, Wilson DM 3rd, Rupp B, J Mol Biol. 2001 Apr 6;307(4):1023-34. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11286553 11286553]
Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism., Beernink PT, Segelke BW, Hadi MZ, Erzberger JP, Wilson DM 3rd, Rupp B, J Mol Biol. 2001 Apr 6;307(4):1023-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11286553 11286553]
[[Category: DNA-(apurinic or apyrimidinic site) lyase]]
[[Category: DNA-(apurinic or apyrimidinic site) lyase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: ref-1]]
[[Category: ref-1]]


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