1ege: Difference between revisions

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[[Image:1ege.jpg|left|200px]]<br /><applet load="1ege" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ege.jpg|left|200px]]
caption="1ege, resolution 2.75&Aring;" />
 
'''STRUCTURE OF T255E, E376G MUTANT OF HUMAN MEDIUM CHAIN ACYL-COA DEHYDROGENASE'''<br />
{{Structure
|PDB= 1ege |SIZE=350|CAPTION= <scene name='initialview01'>1ege</scene>, resolution 2.75&Aring;
|SITE= <scene name='pdbsite=CA1:Catalytic+Base+In+Chain+A'>CA1</scene>, <scene name='pdbsite=CA2:Catalytic+Base+In+Chain+B'>CA2</scene>, <scene name='pdbsite=CA3:Catalytic+Base+In+Chain+C'>CA3</scene> and <scene name='pdbsite=CA4:Catalytic+Base+In+Chain+D'>CA4</scene>
|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE DINUCLEOTIDE'>FAD</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Acyl-CoA_dehydrogenase Acyl-CoA dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.3 1.3.99.3]
|GENE=
}}
 
'''STRUCTURE OF T255E, E376G MUTANT OF HUMAN MEDIUM CHAIN ACYL-COA DEHYDROGENASE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1EGE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FAD:'>FAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Acyl-CoA_dehydrogenase Acyl-CoA dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.3 1.3.99.3] Known structural/functional Sites: <scene name='pdbsite=CA1:Catalytic+Base+In+Chain+A'>CA1</scene>, <scene name='pdbsite=CA2:Catalytic+Base+In+Chain+B'>CA2</scene>, <scene name='pdbsite=CA3:Catalytic+Base+In+Chain+C'>CA3</scene> and <scene name='pdbsite=CA4:Catalytic+Base+In+Chain+D'>CA4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EGE OCA].  
1EGE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EGE OCA].  


==Reference==
==Reference==
Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity., Lee HJ, Wang M, Paschke R, Nandy A, Ghisla S, Kim JJ, Biochemistry. 1996 Sep 24;35(38):12412-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8823176 8823176]
Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity., Lee HJ, Wang M, Paschke R, Nandy A, Ghisla S, Kim JJ, Biochemistry. 1996 Sep 24;35(38):12412-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8823176 8823176]
[[Category: Acyl-CoA dehydrogenase]]
[[Category: Acyl-CoA dehydrogenase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: flavoprotein]]
[[Category: flavoprotein]]


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