1edn: Difference between revisions

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[[~~Image~~:1edn.~~png|left|200px~~]]

==HUMAN ENDOTHELIN-1==

== Structural highlights ==

<table><tr><td colspan='2'>[[1edn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EDN FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1edn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1edn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1edn RCSB], [http://www.ebi.ac.uk/pdbsum/1edn PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by X-ray crystallography to 2.18 A resolution. This intermediate-sized structure was solved by molecular replacement techniques using a fragment of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models derived from NMR data indicate some important differences, especially in the carboxy-terminal region of the molecule: the entire carboxy terminal tail (residues 16-21) is helical in the crystal structure, but not in any of the NMR structures. This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity.

~~{{STRUCTURE_1edn| PDB=1edn | SCENE= }}~~

The crystal structure of human endothelin.,Janes RW, Peapus DH, Wallace BA Nat Struct Biol. 1994 May;1(5):311-9. PMID:7664037<ref>PMID:7664037</ref>

~~===HUMAN ENDOTHELIN-1===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

==~~About this Structure~~==

~~[[1edn]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA].~~

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Janes, R W.]]

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-[[Image:1edn.png|left|200px]]
+==HUMAN ENDOTHELIN-1==
+<StructureSection load='1edn' size='340' side='right' caption='[[1edn]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1edn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EDN FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1edn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1edn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1edn RCSB], [http://www.ebi.ac.uk/pdbsum/1edn PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by X-ray crystallography to 2.18 A resolution. This intermediate-sized structure was solved by molecular replacement techniques using a fragment of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models derived from NMR data indicate some important differences, especially in the carboxy-terminal region of the molecule: the entire carboxy terminal tail (residues 16-21) is helical in the crystal structure, but not in any of the NMR structures. This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity.
-{{STRUCTURE_1edn|  PDB=1edn  |  SCENE=  }}
+The crystal structure of human endothelin.,Janes RW, Peapus DH, Wallace BA Nat Struct Biol. 1994 May;1(5):311-9. PMID:7664037<ref>PMID:7664037</ref>
-===HUMAN ENDOTHELIN-1===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-==About this Structure==
+<references/>
-[[1edn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
 [[Category: Janes, R W.]]