1epp: Difference between revisions

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[[Image:1epp.gif|left|200px]]~~<br /><applet load~~="1epp~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1epp.gif|left|200px]]

~~caption="~~1epp, resolution 1.9Å" />

'''ANALYSES OF LIGAND BINDING IN FIVE ENDOTHIAPEPSIN CRYSTAL COMPLEXES AND THEIR USE IN THE DESIGN AND EVALUATION OF NOVEL RENIN INHIBITORS'''~~<br />~~

{{Structure

|PDB= 1epp |SIZE=350|CAPTION= <scene name='initialview01'>1epp</scene>, resolution 1.9Å

|SITE=

|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAS:DIMETHYLSULFONIC+AMIDE'>MAS</scene> and <scene name='pdbligand=MTF:N-METHYLTHIOFORMAMIDE'>MTF</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22]

|GENE=

}}

'''ANALYSES OF LIGAND BINDING IN FIVE ENDOTHIAPEPSIN CRYSTAL COMPLEXES AND THEIR USE IN THE DESIGN AND EVALUATION OF NOVEL RENIN INHIBITORS'''

==Overview==

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==About this Structure==

1EPP is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] ~~with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=MAS:'>MAS</scene> and <scene name='pdbligand=MTF:'>MTF</scene> as [http://en.wikipedia~~.~~org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22]~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPP OCA].

1EPP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPP OCA].

==Reference==

Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors., Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT, et al., J Med Chem. 1993 Nov 26;36(24):3809-20. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~8254610 8254610]

Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors., Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT, et al., J Med Chem. 1993 Nov 26;36(24):3809-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8254610 8254610]

[[Category: Endothiapepsin]]

[[Category: Single protein]]

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[[Category: hydrolase(acid proteinase)]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:58:47 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1epp.gif|left|200px]]<br /><applet load="1epp" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1epp.gif|left|200px]]
-caption="1epp, resolution 1.9&Aring;" />
-'''ANALYSES OF LIGAND BINDING IN FIVE ENDOTHIAPEPSIN CRYSTAL COMPLEXES AND THEIR USE IN THE DESIGN AND EVALUATION OF NOVEL RENIN INHIBITORS'''<br />
+ {{Structure
+|PDB= 1epp |SIZE=350|CAPTION= <scene name='initialview01'>1epp</scene>, resolution 1.9&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAS:DIMETHYLSULFONIC+AMIDE'>MAS</scene> and <scene name='pdbligand=MTF:N-METHYLTHIOFORMAMIDE'>MTF</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22]
+|GENE=
+}}
+'''ANALYSES OF LIGAND BINDING IN FIVE ENDOTHIAPEPSIN CRYSTAL COMPLEXES AND THEIR USE IN THE DESIGN AND EVALUATION OF NOVEL RENIN INHIBITORS'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-EPP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=MAS:'>MAS</scene> and <scene name='pdbligand=MTF:'>MTF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPP OCA].
+EPP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPP OCA].
 ==Reference==
-Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors., Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT, et al., J Med Chem. 1993 Nov 26;36(24):3809-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8254610 8254610]
+Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors., Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT, et al., J Med Chem. 1993 Nov 26;36(24):3809-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8254610 8254610]
 [[Category: Endothiapepsin]]
 [[Category: Single protein]]
@@ Line 21: / Line 30: @@
 [[Category: hydrolase(acid proteinase)]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:58:47 2008''