1hvp: Difference between revisions

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~~{{Theoretical_model}}~~

==MOLECULAR MODELING OF THE HIV-1 PROTEASE AND ITS SUBSTRATE BINDING SITE==

== Structural highlights ==

<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HVP FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hvp FirstGlance], [http://www.ebi.ac.uk/pdbsum/1hvp PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

The human immunodeficiency virus (HIV-1) encodes a protease that is essential for viral replication and is a member of the aspartic protease family. The recently determined three-dimensional structure of the related protease from Rous sarcoma virus has been used to model the smaller HIV-1 dimer. The active site has been analyzed by comparison to the structure of the aspartic protease, rhizopuspepsin, complexed with a peptide inhibitor. The HIV-1 protease is predicted to interact with seven residues of the protein substrate. This information can be used to design protease inhibitors and possible antiviral drugs.

~~[[Image~~:~~1hvp~~.~~png|left|200px]]~~

Molecular modeling of the HIV-1 protease and its substrate binding site.,Weber IT, Miller M, Jaskolski M, Leis J, Skalka AM, Wlodawer A Science. 1989 Feb 17;243(4893):928-31. PMID:2537531<ref>PMID:2537531</ref>

~~{{STRUCTURE_1hvp| PDB=1hvp | SCENE= }}~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~===MOLECULAR MODELING OF THE HIV-1 PROTEASE AND ITS SUBSTRATE BINDING SITE===~~

== References ==

~~{{ABSTRACT_PUBMED_2537531}}~~

__TOC__

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:002537531<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Weber, I T]]

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@@ Line 1: / Line 1: @@
-{{Theoretical_model}}
+==MOLECULAR MODELING OF THE HIV-1 PROTEASE AND ITS SUBSTRATE BINDING SITE==
+<StructureSection load='1hvp' size='340' side='right' caption='[[1hvp]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HVP FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hvp FirstGlance], [http://www.ebi.ac.uk/pdbsum/1hvp PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The human immunodeficiency virus (HIV-1) encodes a protease that is essential for viral replication and is a member of the aspartic protease family. The recently determined three-dimensional structure of the related protease from Rous sarcoma virus has been used to model the smaller HIV-1 dimer. The active site has been analyzed by comparison to the structure of the aspartic protease, rhizopuspepsin, complexed with a peptide inhibitor. The HIV-1 protease is predicted to interact with seven residues of the protein substrate. This information can be used to design protease inhibitors and possible antiviral drugs.
-[[Image:1hvp.png|left|200px]]
+Molecular modeling of the HIV-1 protease and its substrate binding site.,Weber IT, Miller M, Jaskolski M, Leis J, Skalka AM, Wlodawer A Science. 1989 Feb 17;243(4893):928-31. PMID:2537531<ref>PMID:2537531</ref>
-{{STRUCTURE_1hvp|  PDB=1hvp  |  SCENE=  }}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-===MOLECULAR MODELING OF THE HIV-1 PROTEASE AND ITS SUBSTRATE BINDING SITE===
+== References ==
+<references/>
-{{ABSTRACT_PUBMED_2537531}}
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:002537531</ref><references group="xtra"/>
 [[Category: Weber, I T]]