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[[Image:1lc6.png|left|200px]]
==Solution Structure of the U6 Intramolecular Stem-loop RNA==
<StructureSection load='1lc6' size='340' side='right' caption='[[1lc6]], [[NMR_Ensembles_of_Models | 40 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1lc6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LC6 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lc6 RCSB], [http://www.ebi.ac.uk/pdbsum/1lc6 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
U6 RNA is a key component of the catalytic core of the spliceosome. A metal ion essential for the first catalytic step of pre-mRNA splicing binds to the U80 Sp phosphate oxygen within the yeast U6 intramolecular stem-loop (ISL). Here we present the first structural data for U6 RNA, revealing the three-dimensional structure of the highly conserved U6 ISL. The ISL binds metal ion at the U80 site with the same stereo specificity as the intact spliceosome. The metal-binding site is adjacent to a readily protonated C.A wobble pair. Protonation of the C.A pair and metal binding are mutually antagonistic. These results support a ribozyme model for U6 RNA function and suggest a possible mechanism for the regulation of RNA splicing.


{{STRUCTURE_1lc6|  PDB=1lc6  |  SCENE=  }}
Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure.,Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE Nat Struct Biol. 2002 Jun;9(6):431-5. PMID:11992125<ref>PMID:11992125</ref>


===Solution Structure of the U6 Intramolecular Stem-loop RNA===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_11992125}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1lc6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC6 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:011992125</ref><references group="xtra"/>
[[Category: Allmann, A M.]]
[[Category: Allmann, A M.]]
[[Category: Brow, D A.]]
[[Category: Brow, D A.]]
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