1fin: Difference between revisions
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[[Image:1fin.jpg|left|200px]] | [[Image:1fin.jpg|left|200px]] | ||
'''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX''' | {{Structure | ||
|PDB= 1fin |SIZE=350|CAPTION= <scene name='initialview01'>1fin</scene>, resolution 2.3Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1FIN is a [ | 1FIN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIN OCA]. | ||
==Reference== | ==Reference== | ||
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:[http:// | Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7630397 7630397] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: phosphorylation]] | [[Category: phosphorylation]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:09:38 2008'' | ||
Revision as of 09:09, 20 March 2008
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| 1fin, resolution 2.3Å | |||||||||||||
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| Ligands: | ATP | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
Overview
The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes in its PSTAIRE helix and T-loop. These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.
About this Structure
1FIN is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:7630397
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