1fq5: Difference between revisions

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[[Image:1fq5.jpg|left|200px]]<br /><applet load="1fq5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1fq5.jpg|left|200px]]
caption="1fq5, resolution 2.4&Aring;" />
 
'''X-RAY STRUTURE OF A CYCLIC STATINE INHIBITOR PD-129,541 BOUND TO YEAST PROTEINASE A'''<br />
{{Structure
|PDB= 1fq5 |SIZE=350|CAPTION= <scene name='initialview01'>1fq5</scene>, resolution 2.4&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NPY:NAPHTHALENE'>NPY</scene>, <scene name='pdbligand=NPD:2-METHYL-3-NAPHTHALEN-1-YL-PROPIONALDEHYDE'>NPD</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene> and <scene name='pdbligand=TRJ:META-DI(AMINOMETHYL)BENZENE'>TRJ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Saccharopepsin Saccharopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.25 3.4.23.25]
|GENE=
}}
 
'''X-RAY STRUTURE OF A CYCLIC STATINE INHIBITOR PD-129,541 BOUND TO YEAST PROTEINASE A'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1FQ5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=NDG:'>NDG</scene>, <scene name='pdbligand=NPY:'>NPY</scene>, <scene name='pdbligand=NPD:'>NPD</scene>, <scene name='pdbligand=GLU:'>GLU</scene>, <scene name='pdbligand=STA:'>STA</scene>, <scene name='pdbligand=LEU:'>LEU</scene> and <scene name='pdbligand=TRJ:'>TRJ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Saccharopepsin Saccharopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.25 3.4.23.25] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQ5 OCA].  
1FQ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQ5 OCA].  


==Reference==
==Reference==
X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity., Cronin NB, Badasso MO, J Tickle I, Dreyer T, Hoover DJ, Rosati RL, Humblet CC, Lunney EA, Cooper JB, J Mol Biol. 2000 Nov 10;303(5):745-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11061973 11061973]
X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity., Cronin NB, Badasso MO, J Tickle I, Dreyer T, Hoover DJ, Rosati RL, Humblet CC, Lunney EA, Cooper JB, J Mol Biol. 2000 Nov 10;303(5):745-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11061973 11061973]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharopepsin]]
[[Category: Saccharopepsin]]
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[[Category: ki in nanomolar range]]
[[Category: ki in nanomolar range]]


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