1gih: Difference between revisions

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[[Image:1gih.gif|left|200px]]<br /><applet load="1gih" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1gih.gif|left|200px]]
caption="1gih, resolution 2.8&Aring;" />
 
'''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR'''<br />
{{Structure
|PDB= 1gih |SIZE=350|CAPTION= <scene name='initialview01'>1gih</scene>, resolution 2.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=1PU:1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-PYRIDIN-2-YL-UREA'>1PU</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE=
}}
 
'''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1GIH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=1PU:'>1PU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIH OCA].  
1GIH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIH OCA].  


==Reference==
==Reference==
Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein., Ikuta M, Kamata K, Fukasawa K, Honma T, Machida T, Hirai H, Suzuki-Takahashi I, Hayama T, Nishimura S, J Biol Chem. 2001 Jul 20;276(29):27548-54. Epub 2001 May 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11335721 11335721]
Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein., Ikuta M, Kamata K, Fukasawa K, Honma T, Machida T, Hirai H, Suzuki-Takahashi I, Hayama T, Nishimura S, J Biol Chem. 2001 Jul 20;276(29):27548-54. Epub 2001 May 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11335721 11335721]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: protein kinase]]
[[Category: protein kinase]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:50:25 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:23:32 2008''
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