1gnm: Difference between revisions

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[[Image:1gnm.gif|left|200px]]<br /><applet load="1gnm" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1gnm.gif|left|200px]]
caption="1gnm, resolution 2.3&Aring;" />
 
'''HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)'''<br />
{{Structure
|PDB= 1gnm |SIZE=350|CAPTION= <scene name='initialview01'>1gnm</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=U0E:N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE'>U0E</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE=
}}
 
'''HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1GNM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=U0E:'>U0E</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNM OCA].  
1GNM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNM OCA].  


==Reference==
==Reference==
Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases., Hong L, Treharne A, Hartsuck JA, Foundling S, Tang J, Biochemistry. 1996 Aug 20;35(33):10627-33. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8718851 8718851]
Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases., Hong L, Treharne A, Hartsuck JA, Foundling S, Tang J, Biochemistry. 1996 Aug 20;35(33):10627-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8718851 8718851]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: RNA-directed DNA polymerase]]
[[Category: RNA-directed DNA polymerase]]
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[[Category: u-89360e]]
[[Category: u-89360e]]


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