3dk7: Difference between revisions

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~~[[Image:3dk7.png|left|200px]]~~

==Crystal structure of mutant ABL kinase domain in complex with small molecule fragment==

~~{{STRUCTURE_3dk7| PDB=3dk7 | SCENE= }}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3dk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DK7 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DK7 FirstGlance].

===Crystal structure of mutant ABL kinase domain in complex with small molecule fragment===

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX7:2-AMINO-5-[3-(1-ETHYL-1H-PYRAZOL-5-YL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLBENZAMIDE'>SX7</scene>

<tr><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>

<tr><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[3dk3|3dk3]], [[3dk6|3dk6]]</td></tr>

==~~About this Structure~~==

<tr><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">Abl1, Abl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>

[[3dk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DK7 OCA].

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </td></tr>

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dk7 RCSB], [http://www.ebi.ac.uk/pdbsum/3dk7 PDBsum]</td></tr>

<table>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Check<jmol>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/3dk7_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

</jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

==See Also==

*[[~~Proto-oncogene tyrosine-protein~~ kinase|~~Proto-oncogene tyrosine-protein~~ kinase]]

*[[Tyrosine kinase|Tyrosine kinase]]

__TOC__

</StructureSection>

[[Category: Mus musculus]]

[[Category: Non-specific protein-tyrosine kinase]]

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@@ Line 1: / Line 1: @@
-[[Image:3dk7.png|left|200px]]
+==Crystal structure of mutant ABL kinase domain in complex with small molecule fragment==
+<StructureSection load='3dk7' size='340' side='right' caption='[[3dk7]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
-{{STRUCTURE_3dk7|  PDB=3dk7  |  SCENE=  }}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3dk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DK7 FirstGlance]. <br>
-===Crystal structure of mutant ABL kinase domain in complex with small molecule fragment===
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX7:2-AMINO-5-[3-(1-ETHYL-1H-PYRAZOL-5-YL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLBENZAMIDE'>SX7</scene><br>
+<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3dk3|3dk3]], [[3dk6|3dk6]]</td></tr>
-==About this Structure==
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Abl1, Abl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-[[3dk7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DK7 OCA].
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dk7 RCSB], [http://www.ebi.ac.uk/pdbsum/3dk7 PDBsum]</span></td></tr>
+<table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/3dk7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]
+*[[Tyrosine kinase|Tyrosine kinase]]
+__TOC__
+</StructureSection>
 [[Category: Mus musculus]]
 [[Category: Non-specific protein-tyrosine kinase]]