1gpk: Difference between revisions

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[[Image:1gpk.gif|left|200px]]<br /><applet load="1gpk" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1gpk.gif|left|200px]]
caption="1gpk, resolution 2.10&Aring;" />
 
'''STRUCTURE OF ACETYLCHOLINESTERASE COMPLEX WITH (+)-HUPERZINE A AT 2.1A RESOLUTION'''<br />
{{Structure
|PDB= 1gpk |SIZE=350|CAPTION= <scene name='initialview01'>1gpk</scene>, resolution 2.10&Aring;
|SITE= <scene name='pdbsite=AC1:Hup+Binding+Site+For+Chain+A'>AC1</scene>
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=HUP:HUPERAINE A'>HUP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7]
|GENE=
}}
 
'''STRUCTURE OF ACETYLCHOLINESTERASE COMPLEX WITH (+)-HUPERZINE A AT 2.1A RESOLUTION'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1GPK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=HUP:'>HUP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] Known structural/functional Site: <scene name='pdbsite=AC1:Hup+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GPK OCA].  
1GPK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GPK OCA].  


==Reference==
==Reference==
X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement., Dvir H, Jiang HL, Wong DM, Harel M, Chetrit M, He XC, Jin GY, Yu GL, Tang XC, Silman I, Bai DL, Sussman JL, Biochemistry. 2002 Sep 3;41(35):10810-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12196020 12196020]
X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement., Dvir H, Jiang HL, Wong DM, Harel M, Chetrit M, He XC, Jin GY, Yu GL, Tang XC, Silman I, Bai DL, Sussman JL, Biochemistry. 2002 Sep 3;41(35):10810-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12196020 12196020]
[[Category: Acetylcholinesterase]]
[[Category: Acetylcholinesterase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: alzheimer's disease]]
[[Category: alzheimer's disease]]
[[Category: cholinesterase]]
[[Category: cholinesterase]]
[[Category: huperzine a]]
[[Category: huperzine some]]


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