1h36: Difference between revisions

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[[Image:1h36.gif|left|200px]]~~<br /><applet load~~="1h36~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1h36.gif|left|200px]]

~~caption="~~1h36, resolution 2.8Å" />

'''STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME'''~~<br />~~

{{Structure

|PDB= 1h36 |SIZE=350|CAPTION= <scene name='initialview01'>1h36</scene>, resolution 2.8Å

|SITE= <scene name='pdbsite=C8A:R88+Binding+Site+For+Chain+C'>C8A</scene>

|LIGAND= <scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene> and <scene name='pdbligand=R88:(4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE'>R88</scene>

|ACTIVITY=

|GENE=

}}

'''STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME'''

==Overview==

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==About this Structure==

1H36 is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius] with <scene name='pdbligand=C8E:'>C8E</scene> and <scene name='pdbligand=R88:'>R88</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=C8A:R88+Binding+Site+For+Chain+C'>C8A</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H36 OCA].

1H36 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H36 OCA].

==Reference==

Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase., Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE, J Med Chem. 2003 May 22;46(11):2083-92. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~12747780 12747780]

Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase., Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE, J Med Chem. 2003 May 22;46(11):2083-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12747780 12747780]

[[Category: Alicyclobacillus acidocaldarius]]

[[Category: Single protein]]

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[[Category: cholesterol biosynthesis]]

[[Category: inhibitor]]

[[Category: ~~interactions~~]]

[[Category: interaction]]

[[Category: isomerase]]

[[Category: monotopic membrane]]

[[Category: oxidosqualene cyclase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 12~~:56:51 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:31:33 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1h36.gif|left|200px]]<br /><applet load="1h36" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1h36.gif|left|200px]]
-caption="1h36, resolution 2.8&Aring;" />
-'''STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME'''<br />
+ {{Structure
+|PDB= 1h36 |SIZE=350|CAPTION= <scene name='initialview01'>1h36</scene>, resolution 2.8&Aring;
+|SITE= <scene name='pdbsite=C8A:R88+Binding+Site+For+Chain+C'>C8A</scene>
+|LIGAND= <scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene> and <scene name='pdbligand=R88:(4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE'>R88</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-H36 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius] with <scene name='pdbligand=C8E:'>C8E</scene> and <scene name='pdbligand=R88:'>R88</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=C8A:R88+Binding+Site+For+Chain+C'>C8A</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H36 OCA].
+H36 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H36 OCA].
 ==Reference==
-Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase., Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE, J Med Chem. 2003 May 22;46(11):2083-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12747780 12747780]
+Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase., Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE, J Med Chem. 2003 May 22;46(11):2083-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12747780 12747780]
 [[Category: Alicyclobacillus acidocaldarius]]
 [[Category: Single protein]]
@@ Line 24: / Line 33: @@
 [[Category: cholesterol biosynthesis]]
 [[Category: inhibitor]]
-[[Category: interactions]]
+[[Category: interaction]]
 [[Category: isomerase]]
 [[Category: monotopic membrane]]
 [[Category: oxidosqualene cyclase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:56:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:31:33 2008''