1h6i: Difference between revisions
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[[Image:1h6i.gif|left|200px]] | [[Image:1h6i.gif|left|200px]] | ||
'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1''' | {{Structure | ||
|PDB= 1h6i |SIZE=350|CAPTION= <scene name='initialview01'>1h6i</scene>, resolution 3.54Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
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'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1H6I is a [ | 1H6I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6I OCA]. | ||
==Reference== | ==Reference== | ||
A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:[http:// | A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11532455 11532455] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: water channel]] | [[Category: water channel]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:32:54 2008'' | ||
Revision as of 09:32, 20 March 2008
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A REFINED STRUCTURE OF HUMAN AQUAPORIN 1
Overview
A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.
Disease
Known diseases associated with this structure: Aquaporin-1 deficiency OMIM:[107776], Blood group, Colton OMIM:[107776]
About this Structure
1H6I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455
Page seeded by OCA on Thu Mar 20 11:32:54 2008
