1hbk: Difference between revisions
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[[Image:1hbk.gif|left|200px]] | [[Image:1hbk.gif|left|200px]] | ||
'''ACYL-COA BINDING PROTEIN FROM PLASMODIUM FALCIPARUM''' | {{Structure | ||
|PDB= 1hbk |SIZE=350|CAPTION= <scene name='initialview01'>1hbk</scene>, resolution 2.00Å | |||
|SITE= <scene name='pdbsite=COA:Coa+Binding+Site+For+Chain+A'>COA</scene>, <scene name='pdbsite=MYR:Myr+Binding+Site+For+Chain+A'>MYR</scene>, <scene name='pdbsite=NI1:Ni+Binding+Site+For+Residue+A1091'>NI1</scene> and <scene name='pdbsite=NI2:Ni+Binding+Site+For+Residue+A1092'>NI2</scene> | |||
|LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene> and <scene name='pdbligand=MYR:MYRISTIC ACID'>MYR</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''ACYL-COA BINDING PROTEIN FROM PLASMODIUM FALCIPARUM''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1HBK is a [ | 1HBK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBK OCA]. | ||
==Reference== | ==Reference== | ||
Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein., van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA, J Mol Biol. 2001 May 25;309(1):181-92. PMID:[http:// | Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein., van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA, J Mol Biol. 2001 May 25;309(1):181-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11491287 11491287] | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: fatty acid metabolism]] | [[Category: fatty acid metabolism]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:34:54 2008'' | ||
Revision as of 09:34, 20 March 2008
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| 1hbk, resolution 2.00Å | |||||||||||||
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| Sites: | COA, MYR, NI1 and NI2 | ||||||||||||
| Ligands: | NI, COA and MYR | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
ACYL-COA BINDING PROTEIN FROM PLASMODIUM FALCIPARUM
Overview
Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA molecules in the cell and plays a role in fatty acid metabolism. The biochemical properties of Plasmodium falciparum ACBP are described together with the 2.0 A resolution crystal structures of a P. falciparum ACBP-acyl-CoA complex and of bovine ACBP in two crystal forms. Overall, the bovine ACBP crystal structures are similar to the NMR structures published previously; however, the bovine and parasite ACBP structures are less similar. The parasite ACBP is shown to have a different ligand-binding pocket, leading to an acyl-CoA binding specificity different from that of bovine ACBP. Several non-conservative differences in residues that interact with the ligand were identified between the mammalian and parasite ACBPs. These, together with measured binding-specificity differences, suggest that there is a potential for the design of molecules that might selectively block the acyl-CoA binding site.
About this Structure
1HBK is a Protein complex structure of sequences from Plasmodium falciparum. Full crystallographic information is available from OCA.
Reference
Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein., van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA, J Mol Biol. 2001 May 25;309(1):181-92. PMID:11491287
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